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Post-traumatic creatinuria.

C J Threlfall, A R Maxwell, H B Stoner

    The Journal of Trauma
    |June 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Creatinuria, or excess creatine in urine, increases with injury severity in humans and ischemia duration in rats. This suggests creatinuria can indicate the post-traumatic

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    Area of Science:

    • Biochemistry
    • Physiology
    • Trauma Research

    Background:

    • Musculoskeletal injuries trigger complex metabolic responses.
    • Creatine metabolism alterations are observed following trauma.
    • Understanding post-injury biochemical markers is crucial for patient management.

    Purpose of the Study:

    • To investigate creatinuria following musculoskeletal injuries in humans.
    • To explore the relationship between injury severity and urinary creatine excretion.
    • To elucidate the mechanisms and potential applications of creatinuria as a biomarker.

    Main Methods:

    • Measured urinary outputs of creatine, creatinine, total nitrogen, and 3-methylhistidine in 31 patients.
    • Assessed plasma creatine, creatinine, and guanidinoacetate concentrations in a subset of patients.

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  • Utilized a rat model of bilateral hind-limb ischemia to study urine outputs and tissue creatine, protein, and DNA content.

    • Main Results:

    • Human creatinuria correlated positively with injury severity, more so than creatinine or total nitrogen.
    • In rats, creatinuria was directly related to the duration of limb ischemia.
    • Rat experiments indicated creatine is released from both damaged and undamaged muscle tissue post-injury.

    Conclusions:

    • Creatinuria is a sensitive indicator of musculoskeletal injury severity.
    • The study suggests creatinuria may serve as a biomarker for the post-traumatic 'flow' phase.
    • Further research is warranted to fully understand the clinical utility of monitoring creatinuria.