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Updated: Aug 19, 2026

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
11:13

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

Published on: May 24, 2021

Sequential changes of left ventricular function after cineangiography in normal heart and coronary artery disease

K Kaku, Y Hirota, G Shimizu

    Japanese Circulation Journal
    |June 1, 1984
    PubMed

    Insights

    Contrast material temporarily affects left ventricular (LV) function, causing transient hypotension and altered relaxation. Elevated LV end-diastolic pressure (LVEDP) post-injection suggests acute volume overload, not impaired contractility.

    Area of Science:

    • Cardiology
    • Cardiovascular Physiology

    Background:

    • Left ventricular (LV) function assessment is crucial in cardiology.
    • Contrast agents used in procedures like LV cineangiography can impact cardiac hemodynamics.

    Purpose of the Study:

    • To evaluate the acute effects of contrast material on left ventricular (LV) function.
    • To assess hemodynamic changes in normal subjects and patients with coronary artery disease (CAD) during and after LV cineangiography.

    Main Methods:

    • Continuous monitoring of LV pressure and its first derivative (dP/dt) using Mikro-tip angiocatheters.
    • Study included 4 groups: normal subjects, and CAD patients with no, mild, and severe LV asynergy.
    • Hemodynamic parameters were recorded during and after contrast material injection.

    Main Results:

    • Transient systolic hypotension and decreased negative dP/dt observed post-injection, returning to baseline within 2 minutes.
    • LV end-diastolic pressure (EDP) elevated for up to 7 minutes, correlating with diastolic stiffness in normal subjects.
    • LV contractility indexes (peak positive dP/dt, (dP/dt)/DP40) increased, indicating no intrinsic contractile impairment.

    Conclusions:

    • Systolic hypotension and prolonged relaxation are transient effects of contrast material.
    • Elevated LVEDP post-contrast injection is likely due to acute volume overload.
    • Contrast material does not appear to impair intrinsic LV contractility.

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