[Penetration of cefbuperazone, a new cephamycin antibiotic, into human peritoneal exudate]

Pharmacokinetic studies were carried out on cefbuperazone ( CBPZ ) in 9 patients undergoing postoperative drainage. The concentration of CBPZ in serum and peritoneal exudate after one shot intravenous administration of 1 g was measured by bioassay and calculated respectively by two- and one-compartment open model. The results obtained were as follows: The pharmacokinetic parameters calculated from the serum levels were compared to those reported previously; T1/2 = 101 min., Vd = 4.06 L and Cl = 76 ml/min. The simulation curve of the peritoneal exudate level fit fairly with the mean values of 6 patients. It appeared that CBPZ penetrated somewhat slowly into peritoneal exudate with the peak value of 27.05 micrograms/ml at about 1 hour after the administration. The exudate levels thereafter declined more slowly than the serum ones (T1/2 = 134 min.). IT was 6.2 micrograms/ml even at 6 hours after the administration.