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Related Experiment Videos

[Concentration of piperacillin in bone].

M Kato, R Morimoto

    The Japanese Journal of Antibiotics
    |March 1, 1984
    PubMed
    Summary

    Piperacillin sodium (PIPC) administered intravenously achieved high concentrations in bone tissue. This study measured PIPC levels in serum, cortical bone, and cancellous bone 30 minutes post-injection.

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    [Cytogenetic analysis of lung tumors by in situ hybridization with chromosome-specific DNA probes].

    Nihon Kyobu Shikkan Gakkai zasshi·1992

    Area of Science:

    • Pharmacokinetics
    • Bone Biology
    • Infectious Diseases

    Context:

    • Piperacillin sodium (PIPC) is a widely used antibiotic.
    • Understanding antibiotic penetration into bone is crucial for treating bone infections.
    • Limited data exists on PIPC concentrations within human bone tissue.

    Purpose:

    • To quantify piperacillin sodium concentrations in human serum and bone.
    • To evaluate the extent of PIPC penetration into cancellous and cortical bone.

    Summary:

    • Eighteen patients received 2.0 grams of intravenous piperacillin sodium.
    • Serum, cancellous bone, and cortical bone samples were collected 30 minutes post-injection.
    • Mean serum PIPC concentration was 95.61 µg/ml, mean cancellous bone concentration was 8.07 µg/g, and mean cortical bone concentration was 4.58 µg/g.

    Impact:

    • Piperacillin sodium demonstrates significant penetration into human bone tissue.
    • These findings support the potential efficacy of piperacillin sodium in treating bone infections.
    • Provides valuable pharmacokinetic data for optimizing antibiotic therapy in orthopedic infections.

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