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Amoxapine in human overdose.

J J Tasset, A J Pesce

Journal of Analytical Toxicology

|May 1, 1984

Summary

This summary is machine-generated.

Amoxapine overdose in patients leads to seizures and cardiac issues. The parent drug and its 8-hydroxy metabolite are found in urine and serum, similar to normal doses.

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Area of Science:

Pharmacology
Clinical Toxicology

Background:

Amoxapine is a tricyclic antidepressant.
Limited data exists on amoxapine metabolism and clinical symptoms in overdose cases.

Purpose of the Study:

To investigate amoxapine metabolism in overdose patients.
To correlate clinical symptoms with drug and metabolite levels.

Main Methods:

Studied five overdose patients admitted to the emergency unit.
Measured parent drug and 7- and 8-hydroxyamoxapine levels in serum and urine.
Utilized gas chromatography/mass spectrometry for analysis.

Main Results:

All patients experienced seizures and altered cardiac function.
Parent amoxapine and 8-hydroxyamoxapine were consistently found in serum and urine.

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7-hydroxyamoxapine was detected in urine of all patients and serum of two.

Metabolism patterns resembled those in patients on maintenance doses.

Conclusions:

Amoxapine overdose is associated with significant clinical toxicity, including seizures and cardiac dysfunction.
The metabolic profile in overdose is similar to therapeutic use, with 8-hydroxyamoxapine being a major metabolite.
Further research into amoxapine toxicity and metabolism is warranted.