Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mitral stenosis associated with valvular tophi.

J N Scalapino, W D Edwards, J M Steckelberg

    Mayo Clinic Proceedings
    |July 1, 1984
    PubMed
    Summary

    Chronic tophaceous gout is rare, especially in the heart. This case highlights valvular tophi causing severe mitral stenosis, a condition rarely seen with gouty deposits.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    International experts' practice in the antibiotic therapy of infective endocarditis is not following the guidelines.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2017
    Same author

    The Medical Bookshelf.

    Postgraduate medicine·2016
    Same author

    Temporal changes in the surgical pathology of prosthetic aortic valves: a study of 157 cases spanning 26 years (1970-1995).

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
    Same author

    Pulmonary hypertension attributable to neoplastic emboli: An autopsy study of 20 cases and a review of literature.

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
    Same author

    Plexogenic pulmonary hypertension in systemic lupus erythematosus: Report of two cases and review of the literature.

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
    Same author

    Amyloidosis and endomyocardial biopsy: Correlation of extent and pattern of deposition with amyloid immunophenotype in 100 cases.

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015

    Area of Science:

    • Cardiology
    • Rheumatology
    • Pathology

    Background:

    • Chronic tophaceous gout, characterized by urate crystal deposition, has decreased due to effective urate-lowering therapies like allopurinol and probenecid.
    • Cardiac involvement in gout, particularly tophi formation within heart valves, is exceptionally rare in medical literature.

    Observation:

    • A rare case of severe mitral stenosis was identified.
    • The mitral valve was significantly affected by tophaceous deposits, suggesting a primary role in the stenosis pathogenesis.

    Findings:

    • Echocardiography, surgical pathology, and chemical analysis confirmed the presence of valvular tophi as the cause of severe mitral stenosis.
    • The findings demonstrate a direct link between gouty deposits and significant valvular heart disease.

    Implications:

    • This case underscores the importance of considering uncommon etiologies for valvular heart disease, even in the context of reduced gout prevalence.
    • Understanding the pathogenesis of valvular tophi can inform diagnostic and therapeutic strategies for rare cardiac manifestations of chronic gout.

    Related Experiment Videos