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Related Experiment Videos

Fibrin generation in normal pregnancy.

C P Weiner, H Kwaan, W W Hauck

    Obstetrics and Gynecology
    |July 1, 1984
    PubMed
    Summary

    Pregnancy increases thrombin generation, indicated by elevated fibrinopeptide A (FPA) levels. This confirms a hypercoagulable state throughout gestation and postpartum.

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    Area of Science:

    • Obstetrics and Gynecology
    • Hematology
    • Thrombosis Research

    Background:

    • Pregnancy is associated with a hypercoagulable state.
    • Existing laboratory markers lack specificity for thrombosis during pregnancy.
    • Thrombin generation is a key factor in hemostasis and thrombosis.

    Purpose of the Study:

    • To prospectively measure fibrinopeptide A (FPA) levels during pregnancy.
    • To assess thrombin generation as an indicator of the hypercoagulable state in pregnancy.
    • To correlate FPA levels with gestational age.

    Main Methods:

    • Radioimmunoassay was used to quantify FPA levels.
    • FPA was measured in a longitudinal and cross-sectional study design.
    • Measurements were taken throughout pregnancy and the postpartum period.

    Main Results:

    • Fibrinopeptide A (FPA) levels significantly increased by the first trimester (1.3 to 2.8 ng/ml).
    • FPA levels continued to rise until 30-32 weeks' gestation, plateauing at 4.3-4.7 ng/ml.
    • Elevated FPA levels persisted into the immediate postpartum period.

    Conclusions:

    • Thrombin generation is significantly increased throughout pregnancy.
    • Elevated FPA levels confirm a hypercoagulable milieu during pregnancy.
    • FPA serves as a sensitive marker for increased thrombin generation in pregnancy.

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