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A multifactorial pregnancy outcome index.

L P Petersen, D Witzke, J Gergen

Obstetrics and Gynecology

|August 1, 1984

Summary

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This study developed a seven-factor pregnancy outcome index. Maternal serum copper levels, not estriol or zinc, significantly predicted pregnancy outcomes, with low copper indicating good outcomes.

Area of Science:

Obstetrics and Gynecology
Maternal-Fetal Medicine
Biochemistry

Background:

Pregnancy outcome assessment traditionally relies on various clinical factors.
A comprehensive, multifactorial index is needed for accurate pregnancy outcome evaluation.
Previous studies have explored biochemical markers, with varying success.

Purpose of the Study:

To develop and validate a multifactorial index for assessing pregnancy outcome.
To investigate the relationship between maternal serum copper, estriol, and zinc levels and pregnancy outcome.
To identify potential novel biochemical predictors of pregnancy success.

Main Methods:

A multifactorial pregnancy outcome index was created based on seven clinical factors.
Clinical data from 821 subjects, including 102 high-risk patients, were analyzed.

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Correlation analyses were performed between the outcome index and maternal serum biomarkers (estriol, zinc, copper).

Main Results:

The multifactorial index demonstrated validation against established pregnancy outcome indicators.
Maternal serum copper levels showed a significant, systematic relationship with pregnancy outcome across all trimesters.
No significant correlation was found between pregnancy outcome and maternal serum estriol or zinc levels.

Conclusions:

Maternal serum copper levels may serve as a valuable and alternative predictor of pregnancy outcome.
The developed multifactorial index provides a robust method for assessing pregnancy success.
Further research is warranted to confirm copper's role in predicting pregnancy outcomes.