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Related Experiment Videos

What is atopy? Sidestepping semantics.

H S Nelson

    Postgraduate Medicine
    |July 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Atopy, a condition with diverse symptoms like eczema and asthma, involves immune and nervous system dysregulation. Research suggests underlying defects may involve T-cell deficiencies and altered adrenergic functions, impacting allergic responses.

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    Area of Science:

    • Immunology
    • Allergy
    • Autonomic Nervous System

    Background:

    • Atopy encompasses a spectrum of conditions including eczema, asthma, and rhinitis, often clustering within families.
    • These conditions share clinical findings and are frequently associated with immune and autonomic nervous system derangements.
    • Eosinophils are characteristic in affected tissues, irrespective of immediate hypersensitivity, and mast-cell mediator release symptoms are common.

    Purpose of the Study:

    • To explore the underlying defects in atopy.
    • To investigate the relationship between atopic diseases, immune responses, and autonomic nervous system function.

    Main Methods:

    • Review of clinical findings in atopic diseases.
    • Analysis of immune system parameters, including IgE responses and T-cell function.

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  • Assessment of autonomic nervous system responsiveness (adrenergic and cholinergic).

    • Main Results:

    • Approximately 80% of patients with eczema and asthma show increased IgE responses to allergens.
    • Deficiencies in T-cell numbers and function, particularly suppressor T lymphocytes, are noted.
    • Evidence suggests decreased beta 2-adrenergic function and increased cholinergic and alpha-adrenergic responsiveness in atopic individuals.

    Conclusions:

    • Atopy may stem from an undefined defect involving immune and autonomic nervous system dysregulation.
    • Enhanced IgE responses and T-cell deficiencies are linked to atopic diseases.
    • Altered adrenergic and cholinergic functions appear to be associated with the pathogenesis of atopic conditions, regardless of allergic status.