Indocyanine green clearance following single and chronic cimetidine doses

Twenty-five indocyanine green (ICG) clearance determinations were performed in four subjects in the presence of quinidine or propranolol before and after one week of treatment with cimetidine, 1200 mg/day, and following a single 600 mg cimetidine dose. There was no significant difference between the mean ICG clearance before cimetidine treatment and that after one week of therapy with cimetidine, while the mean ICG clearance was 25% lower following single cimetidine doses (p greater than 0.05). It is concluded that cimetidine has only a transient hepatic blood flow lowering effect.