Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Poliomyelitis control in Japan.

H Shimojo

    Reviews of Infectious Diseases
    |May 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    The Sabin oral poliovirus vaccine (OPV) significantly reduced paralytic polio in Japan. Ensuring high-quality vaccine batches is crucial for maintaining OPV's safety and effectiveness against poliovirus.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Skin-limited arteritis of small muscular arteries with giant cell-rich granulomatous inflammation in a patient with polymyalgia rheumatica.

    Scandinavian journal of rheumatology·2018
    Same author

    Overexpression of O-GlcNAc by prostate cancer cells is significantly associated with poor prognosis of patients.

    Prostate cancer and prostatic diseases·2013
    Same author

    Clinical features of a new disease concept, IgG4-related thyroiditis.

    Scandinavian journal of rheumatology·2013
    Same author

    Stable suspension for Vi-agglutination tests.

    Bulletin of the World Health Organization·2010
    Same author

    The effects of various therapeutic measures on shoulder range of motion and cross-sectional areas of rotator cuff muscles after baseball pitching.

    The Journal of sports medicine and physical fitness·2003
    Same author

    The effects of various therapeutic measures on shoulder strength and muscle soreness after baseball pitching.

    The Journal of sports medicine and physical fitness·2003

    Area of Science:

    • * Virology
    • * Immunology
    • * Public Health

    Background:

    • * The Sabin oral poliovirus vaccine (OPV) has been a cornerstone of polio eradication efforts globally and in Japan since 1961.
    • * Widespread OPV use in Japan led to a marked decrease in paralytic poliomyelitis cases.
    • * Variations in vaccine efficacy and safety have been observed, necessitating ongoing monitoring.

    Purpose of the Study:

    • * To analyze the incidence of paralytic poliomyelitis and antibody response rates in relation to OPV use in Japan.
    • * To investigate the impact of different poliovirus vaccine batches on disease incidence and antibody titers.
    • * To determine the critical role of vaccine batch quality in ensuring the safety and efficacy of OPV.

    Main Methods:

    • * Retrospective analysis of paralytic poliomyelitis case data and serological antibody surveys.

    Related Experiment Videos

  • * Correlation of poliovirus types (1, 2, and 3) with paralytic case incidence.
  • * Evaluation of neutralizing antibody titers in response to specific OPV batches administered over time.

    • Main Results:

    • * Paralytic cases associated with OPV were low for type 1, high for type 2, and initially high for type 3 before 1970.
    • * Changes in the type 3 virus batch used in OPV correlated with a decrease in associated paralytic cases after 1970.
    • * Inadequate antibody responses were observed for type 1 (1977) and type 3 (1972-1973) OPV batches, which improved after batch modification.

    Conclusions:

    • * The quality and specific virus batches used in oral poliovirus vaccine (OPV) significantly impact its efficacy and safety.
    • * Continuous monitoring and selection of optimal virus batches are essential for maintaining effective polio immunization programs.
    • * These findings underscore the importance of stringent quality control in vaccine production for public health success.