Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Urinary nicotine concentrations in cigarette and pipe smokers.

N J Wald, M Idle, J Boreham

    Thorax
    |May 1, 1984
    PubMed
    Summary

    Nicotine levels in urine were higher in cigarette and pipe smokers compared to non-smokers. This suggests nicotine is unlikely the main cause of coronary heart disease deaths in cigarette smokers.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Multi-disciplinary support of infant feeding choice for parents living with HIV: experience across a guideline change.

    Frontiers in reproductive health·2026
    Same author

    Chewing analysis of horses consuming bermudagrass hay in different styles of slow feeders as compared to loose hay.

    Journal of equine veterinary science·2024
    Same author

    Real-world clinical profile, treatment patterns and patient-reported outcomes in a subset of HR+/HER2- advanced breast cancer patients with poor prognostic factors: data from an international study.

    ESMO open·2021
    Same author

    Staff and participant perceptions of optimal recruitment and retention strategies for biomedical cohort studies in the Caribbean.

    Cancer causes & control : CCC·2021
    Same author

    Objective and subjective rapid frailty screening tools in people with HIV.

    HIV medicine·2020
    Same author

    Oxytocin reduces post-stress sweet snack intake in women without attenuating salivary cortisol.

    Physiology & behavior·2019

    Area of Science:

    • Toxicology
    • Cardiovascular Health
    • Smoking Cessation Research

    Background:

    • Nicotine is a primary psychoactive compound in tobacco products.
    • Systemic nicotine concentrations are influenced by smoking habits.
    • Coronary heart disease (CHD) risk is elevated in cigarette smokers.

    Purpose of the Study:

    • To compare urinary nicotine concentrations in cigarette smokers, pipe smokers, and non-smokers.
    • To investigate the relationship between nicotine exposure and CHD risk.
    • To evaluate nicotine's role as a potential cause of excess CHD mortality in smokers.

    Main Methods:

    • Measured urinary nicotine concentrations in 27 non-smokers, 145 cigarette smokers, and 48 pipe smokers.
    • Standardized nicotine levels for urinary pH and creatinine concentration.
    • Compared median urinary nicotine concentrations across smoking groups.

    Main Results:

    • Median urinary nicotine: <50 ng/ml (non-smokers), 1393 ng/ml (cigarette smokers), 1048 ng/ml (pipe smokers).
    • High urinary nicotine confirmed significant systemic exposure in both cigarette and pipe smokers.
    • Pipe smokers show no excess CHD risk, unlike cigarette smokers.

    Conclusions:

    • Nicotine exposure is substantial in both cigarette and pipe smokers.
    • Nicotine is unlikely to be the primary driver of excess coronary heart disease mortality observed in cigarette smokers.
    • Findings align with previous cotinine level studies, supporting nicotine's limited role in smoking-related CHD.

    Related Experiment Videos