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[Modification of virulence and immunogenicity of Pasteurella multocida by iron in vitro]

K D Flossmann, H Rosner, U Grünke

    Zeitschrift Fur Allgemeine Mikrobiologie
    |January 1, 1984
    PubMed

    Insights

    Iron levels in growth media significantly impact Pasteurella multocida virulence and immunogenicity in mice. Iron deficiency during bacterial cultivation reduces the pathogen's ability to cause disease.

    Area of Science:

    • Microbiology
    • Bacterial Pathogenesis
    • Immunology

    Context:

    • Pasteurella multocida is a significant bacterial pathogen.
    • Bacterial virulence is influenced by environmental factors.
    • Iron availability is crucial for bacterial growth and function.

    Purpose:

    • To investigate the role of iron in Pasteurella multocida virulence.
    • To determine if iron affects bacterial immunogenicity.
    • To explore iron's regulatory effect on virulence factors.

    Summary:

    • Bacterial virulence in experimental mouse infections correlated with iron content in cultivation media.
    • Frequent subculturing on iron-deficient media markedly decreased Pasteurella multocida virulence.
    • One strain exhibited reduced immunogenicity following iron-deficient passages.

    Impact:

    • Iron likely regulates the production of an unidentified virulence factor in Pasteurella multocida.
    • Findings suggest iron availability as a key determinant of P. multocida pathogenicity.
    • This research provides insights into controlling bacterial infections by manipulating nutrient availability.

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