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[Psoriasis therapy with fumaric acid and fumaric acid esters].
Zeitschrift Fur Hautkrankheiten
|May 15, 1984
Summary
Fumaric acid shows limited direct benefit for psoriasis, with effects possibly due to secondary stomach acid changes. Monoethylfumarate has antipsoriatic properties but is too toxic for use.
Area of Science:
- Biochemistry
- Dermatology
- Pharmacology
Context:
- Psoriasis is a chronic inflammatory skin condition.
- Fumaric acid and its derivatives are investigated for therapeutic potential.
- Understanding the mechanism of action is crucial for drug development.
Purpose:
- To evaluate the efficacy of fumaric acid as an antipsoriatic agent.
- To investigate the mechanism underlying any observed therapeutic effects.
- To assess the potential of monoethylfumarate as a psoriasis treatment.
Summary:
- Fumaric acid's benefits for psoriasis may stem from secondary effects like gastric acid acidification, not direct action.
- Monoethylfumarate demonstrates genuine antipsoriatic activity but exhibits significant toxicity, precluding clinical application.
- In vitro studies show fumarates inhibit nucleic acid and protein synthesis in lymphocytes.
Impact:
- Fumaric acid is unlikely to be a primary treatment for psoriasis.
- Monoethylfumarate's toxicity limits its therapeutic use.
- Further research into fumarate derivatives may yield safer, effective treatments for psoriasis.