[Immunologic sensitization to tumor-associated antigens during the growth of gliomas of the brain (experimental...

The reactions of cellular immunity to malignant gliomas of the rat brain were studied by measuring the electrophoretic mobility of indicator cells (the EPM test). The appearance of sensitization coincided in time with the development of the glioma's own vascular network possessing no barrier function. The sensitization was constant in character and persisted till the death of the tumor-carriers. The EPM test did not reveal qualitative differences in sensitization in intracerebral and subcutaneous glioma growth.