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Related Experiment Videos

Trihexyphenidyl dependence.

M McInnis, H Petursson

    Acta Psychiatrica Scandinavica
    |June 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Trihexyphenidyl abuse is a growing concern. A case study revealed a withdrawal syndrome, suggesting dependence liability should be considered during treatment.

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    Area of Science:

    • Pharmacology
    • Clinical Neurology
    • Addiction Medicine

    Background:

    • Trihexyphenidyl is a synthetic anticholinergic medication.
    • It is commonly prescribed with neuroleptics to manage extrapyramidal side effects.
    • Concerns regarding its abuse potential are increasing.

    Observation:

    • Two cases of trihexyphenidyl abuse are presented.
    • One case involved a double-blind, placebo-controlled withdrawal.
    • Physiological parameters and the Hamilton Anxiety Rating Scale were monitored during withdrawal.

    Findings:

    • A distinct withdrawal syndrome was observed upon discontinuation of trihexyphenidyl.
    • This supports the potential for abuse and dependence with this medication.

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    Implications:

    • The findings suggest that the abuse potential and dependence liability of trihexyphenidyl warrant consideration.
    • Clinicians should carefully evaluate patients during maintenance therapy with trihexyphenidyl and other antiparkinsonian drugs.
    • Further research into the long-term effects and management of trihexyphenidyl dependence is recommended.