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Related Experiment Videos

Bone marrow biopsy technic. Artifact induced by aspiration.

D D Douglas, R J Risdall

    American Journal of Clinical Pathology
    |July 1, 1984
    PubMed
    Summary

    Performing bone marrow trephine biopsy before aspiration minimizes artifact, ensuring accurate marrow disorder assessment. This procedural order is crucial for reliable diagnostic evaluation, especially with limited trephine samples.

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    Area of Science:

    • Hematology
    • Anatomic Pathology
    • Diagnostic Procedures

    Background:

    • Bone marrow aspiration and trephine biopsy are essential for diagnosing marrow disorders.
    • The optimal sequence for obtaining these specimens is debated among clinicians.
    • Performing trephine biopsy after aspiration may introduce artifacts like hypocellularity and hemorrhage.

    Purpose of the Study:

    • To describe the occurrence and significance of bone marrow aspiration artifact.
    • To provide recommendations for optimizing bone marrow biopsy procedures.

    Main Methods:

    • Analysis of bone marrow specimens where aspiration preceded trephine biopsy.
    • Comparison of artifact presence and impact on diagnostic quality.
    • Evaluation of specimen quality based on the relative order of aspiration and trephine biopsy.

    Main Results:

    • Bone marrow aspiration artifact, characterized by hypocellularity and hemorrhage, can occur in trephine biopsy specimens.
    • This artifact typically occupies a small area, but can hinder evaluation, particularly in short trephine samples.
    • Artifacts are absent in trephine specimens taken from sites distant from aspiration.

    Conclusions:

    • Performing trephine biopsy before aspiration is recommended to avoid aspiration-induced artifacts.
    • Alternatively, trephine biopsy should be performed at a separate site if aspiration precedes it.
    • These measures are especially important when obtaining adequate trephine material is challenging.

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