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Intrinsic emptying pattern of the human stomach
The American Journal of Physiology
|June 1, 1984
Summary
Gastric emptying follows an exponential pattern, with minimal slowing observed when duodenal receptors are stimulated by 120 mM sodium chloride (NaCl) solutions. This study clarifies intrinsic gastric emptying dynamics.
Area of Science:
- Gastroenterology
- Physiology
Background:
- Gastric emptying is a complex physiological process influenced by various factors.
- Understanding the intrinsic pattern of gastric emptying is crucial for diagnosing and managing gastrointestinal disorders.
Purpose of the Study:
- To determine the intrinsic gastric emptying pattern in humans.
- To investigate the effect of duodenal receptors on gastric emptying using saline solutions.
Main Methods:
- Twenty-three subjects consumed 750 ml saline meals.
- Gastric content was recovered at 5, 10, and 20 minutes post-ingestion.
- Statistical analysis using within-subject regressions and an exponential model was performed.
Main Results:
- Gastric emptying data were best described by an exponential model when initial volume was included.
- A 120 mM sodium chloride (NaCl) solution minimally slowed gastric emptying, indicating a minor role for duodenal receptors in this context.
Conclusions:
- The intrinsic pattern of human gastric emptying can be accurately modeled exponentially.
- Duodenal receptors exert minimal inhibitory control over gastric emptying when stimulated by a 120 mM NaCl solution.
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