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Related Experiment Videos

Cobalt lung in diamond polishers.

M Demedts, B Gheysens, J Nagels

    The American Review of Respiratory Disease
    |July 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

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    Cobalt exposure from diamond polishing tools caused interstitial lung disease in five workers. Prompt removal from exposure led to symptom relief and improved lung function.

    Area of Science:

    • Occupational Medicine
    • Toxicology
    • Pulmonary Medicine

    Background:

    • Diamond polishers can be exposed to cobalt, a metal not alloyed to hard metal carbides.
    • High-speed grinding tools with microdiamond polishing surfaces cemented in cobalt pose an exposure risk.

    Observation:

    • Five diamond polishers developed interstitial lung disease linked to cobalt exposure.
    • Symptoms included rhinitis, cough, chest tightness, dyspnea, anorexia, and weight loss, worsening with inadequate ventilation.
    • Mineralogic analysis confirmed cobalt as the sole toxic agent in lung tissue, lavage fluid, and environmental dust.

    Findings:

    • Subacute and chronic interstitial lung disease patterns were observed, with fibrosing alveolitis in the centrilobular zones.
    • Subacute cases showed mononuclear cell infiltrate, desquamation, and giant cells; chronic cases exhibited fibrosis and microcysts.

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  • Bronchoalveolar lavage fluid contained multinucleated giant cells, indicating an inflammatory response.

    • Implications:

    • Occupational cobalt exposure is a significant risk factor for interstitial lung disease.
    • Early diagnosis and removal from exposure are crucial for managing cobalt-induced lung disease.
    • Adequate ventilation systems are essential to mitigate exposure risks in diamond polishing environments.