2-Deoxy-D-glucose induced feeding: relation to diet palatability

Area of Science:

• Physiology
• Animal Behavior
• Neuroscience

Background:

• Diet palatability is a critical factor influencing food intake.
• Understanding how taste affects feeding behavior is essential for metabolic research.

Purpose of the Study:

• To investigate the role of diet palatability in modulating the feeding response to 2-deoxy-D-glucose (2-DG).
• To determine if quinine adulteration of a standard diet affects 2-DG-induced feeding in rats.

Main Methods:

• Adult male rats were fed either standard Purina Laboratory Chow or chow adulterated with 0.5% quinine hydrochloride.
• Rats received intraperitoneal injections of three doses of 2-DG (250, 500, 750 mg/kg) or physiological saline.
• Food intake was measured over a six-hour test period following injections.

Main Results:

• Rats fed standard chow showed a significant increase in food intake after 2-DG injections (250 and 500 mg/kg) compared to saline.
• Rats fed quinine-adulterated chow did not exhibit increased food intake in response to 2-DG and showed decreased intake at the highest dose.
• Palatability of the diet critically influenced the rats' feeding response to 2-DG.

Conclusions:

• Diet palatability plays a significant role in the physiological regulation of feeding behavior.
• The sensory properties of food can override or attenuate appetite-stimulating signals like those induced by 2-DG.
• These findings highlight the complex interplay between taste, hunger, and food consumption.