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Related Experiment Videos

Tick resistance and the major histocompatibility system.

M J Stear, M J Newman, F W Nicholas

    The Australian Journal of Experimental Biology and Medical Science
    |February 1, 1984
    PubMed
    Summary

    Researchers investigated bovine lymphocyte antigens for links to cattle tick resistance in Brahman-Shorthorn cattle. While some associations were found, they were not strong enough to be highly predictive of tick resistance or susceptibility.

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    Scientific reports·2020

    Area of Science:

    • Animal Genetics
    • Veterinary Entomology
    • Immunology

    Background:

    • Cattle tick (Boophilus microplus) infestations cause significant economic losses in cattle production worldwide.
    • Genetic resistance in cattle is a key strategy for sustainable tick control.
    • Bovine lymphocyte antigens (BoLA) play a role in immune responses, potentially influencing disease resistance.

    Purpose of the Study:

    • To determine if specific bovine lymphocyte antigens are associated with resistance or susceptibility to the cattle tick Boophilus microplus.
    • To evaluate the strength of these associations in a mixed-breed cattle population.

    Main Methods:

    • Nineteen bovine lymphocyte antigens were tested in 199 3/4 Brahman 1/4 Shorthorn cattle.
    • Cattle tick resistance was previously established through clinical trials.

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  • Statistical analysis was used to identify associations between BoLA antigens and tick resistance phenotypes.

    • Main Results:

    • Eleven bovine lymphocyte antigens were detected at a frequency greater than 5%.
    • Two of these antigens showed a statistical association with tick resistance.
    • One antigen was associated with susceptibility to cattle tick infestation.
    • The identified associations explained less than 2.1% of the variance in tick resistance.

    Conclusions:

    • Specific bovine lymphocyte antigens show a weak association with cattle tick resistance and susceptibility.
    • BoLA typing alone is unlikely to be a strong predictor of tick resistance in this cattle breed composition.
    • Further research is needed to identify stronger genetic markers for tick resistance.