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Updated: Sep 20, 2026

Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction
07:41

Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction

Published on: June 7, 2011

Angiographic features of the coronary arteries during intracoronary thrombolysis

P Terrosu, G V Ibba, G M Contini

    British Heart Journal
    |August 1, 1984
    PubMed

    Insights

    Successful thrombolysis with urokinase in acute myocardial infarction reveals distinct angiographic phases. These phases track coronary artery recanalization, from complete occlusion to restored, smooth blood flow.

    Area of Science:

    • Cardiology
    • Interventional Cardiology
    • Radiology

    Background:

    • Acute myocardial infarction (AMI) is a leading cause of mortality.
    • Coronary artery thrombosis is the primary cause of AMI.
    • Thrombolytic therapy aims to restore coronary blood flow.

    Purpose of the Study:

    • To describe the sequential angiographic changes during successful urokinase thrombolysis in patients with AMI.
    • To identify specific angiographic features indicative of coronary thrombosis.

    Main Methods:

    • 35 patients with acute myocardial infarction undergoing successful thrombolysis with urokinase were studied.
    • Coronary angiography was performed to visualize the angiographic appearance of coronary arteries.
    • The process of thrombolysis was analyzed in distinct phases based on lumen patency and flow characteristics.

    Main Results:

    • Five distinct angiographic phases of thrombolysis were identified, ranging from total occlusion (Phase 0) to a widely patent lumen (Phase 4).
    • Key phases included increasing patency, re-establishment of flow with filling defects (microemboli), and resolution of defects.
    • Angiographic indicators of coronary thrombosis included irregular or scalloped margins, contrast staining, and progressive patency with intraluminal defects.

    Conclusions:

    • Successful thrombolysis with urokinase demonstrates a predictable series of angiographic changes.
    • Specific angiographic findings can reliably indicate the presence of coronary thrombosis.
    • Understanding these phases aids in evaluating the efficacy of thrombolytic therapy for acute myocardial infarction.

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