Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human amniotic membrane and prostaglandin biosynthesis.

K Kinoshita, K Satoh, S Sakamoto

    Biological Research in Pregnancy and Perinatology
    |January 1, 1984
    PubMed
    Summary

    The human amnion is a key site for prostaglandin biosynthesis, producing PGE2 as a primary product. This suggests the amnion plays a crucial role in initiating and maintaining labor through prostaglandin production.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effects of eicosapentaenoic and docosahexaenoic acid on cell growth and prostaglandin E and leukotriene B production by a human breast cancer cell line (MDA-MB-231).

    Oncology·1995
    Same author

    [A case of ovarian malignant Sertoli-Leidig cell tumor treated with CBDCA, etoposide and epirubicin chemotherapy].

    Gan to kagaku ryoho. Cancer & chemotherapy·1995
    Same author

    [Clinical investigation of renal pelvic and ureteral cancer with special reference to adjuvant chemotherapy].

    Nihon Hinyokika Gakkai zasshi. The japanese journal of urology·1995
    Same author

    p93dis1, which is required for sister chromatid separation, is a novel microtubule and spindle pole body-associating protein phosphorylated at the Cdc2 target sites.

    Genes & development·1995
    Same author

    [A patient-controlled analgesia system using a disposable balloon catheter, a PCA polyethylene reservoir and a one-way umbrella check valve].

    Masui. The Japanese journal of anesthesiology·1995
    Same author

    Effect of activin and lithium on isolated Xenopus animal blastomeres and response alteration at the midblastula transition.

    Development (Cambridge, England)·1995

    Area of Science:

    • Reproductive biology
    • Biochemistry
    • Obstetrics

    Background:

    • The human amnion is involved in metabolizing biologically active substances like steroid hormones and prostaglandins.
    • Prostaglandins are implicated in the initiation and maintenance of labor.

    Purpose of the Study:

    • To investigate prostaglandin biosynthesis in the human amnion.
    • To determine the role of prostaglandins in initiating and maintaining labor.

    Main Methods:

    • Investigated prostaglandin sources in amniotic fluid.
    • Assessed prostaglandin generation activity in amnion, chorion laeve, and decidua vera.
    • Analyzed bioconversion of arachidonic acid in human amnion homogenates.
    • Compared PGE2 production in amnions from vaginal delivery versus cesarean section.

    Main Results:

    • The amnion exhibited the highest prostaglandin-generating activity compared to other placental tissues.
    • Prostaglandin E2 (PGE2) was the main product, with a 5% conversion rate of arachidonic acid.
    • Cyclooxygenase produced PGF2 alpha, TXB2, and HHT; lipoxygenase produced 15-HETE and 9, 11, 12-HETE.
    • PGE2 production was significantly higher in amnions from normal vaginal deliveries than from pre-labor cesarean sections.

    Conclusions:

    • The human amnion plays a significant role in prostaglandin biosynthesis within uterine tissues.
    • These findings support the involvement of amnion-derived prostaglandins in the physiological processes of labor initiation and maintenance.

    Related Experiment Videos