[Specificity of liposome uptake from target cell lipids]

A more considerable uptake of liposomes (1.5-2 times greater) from lipids of target cells was revealed in the cells of ascites lympholeukemia NKLy/LL and Ehrlich's ascites carcinoma as compared with liposomes from other tumor lipids. NKLy/LL cells uptake liposomes from their own lipids 8 times as effective, whereas Ehrlich's carcinoma cells 3 times as effective as widely applied vesicles from egg lecithin. Evidence is provided that the differences discovered are consequent on the different mechanisms of liposome interaction with the cells. As far as egg lecithin is concerned, the principal mechanism of interaction is endocytosis which is unmarked in these cells. Meanwhile uptake of target cell lipids is effected by the fusion mechanism.