Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Beer drinking and its effect on uric acid.

T Gibson, A V Rodgers, H A Simmonds

    British Journal of Rheumatology
    |August 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Chronic hemolytic anemia and accumulation of pyrimidine nucleotide metabolites.

    International journal of laboratory hematology·2014
    Same author

    Purine and pyrimidine excretion in psoriasis: a comparison with healthy controls during allopurinol therapy.

    British journal of clinical pharmacology·2012
    Same author

    Thiopurinol: comparative enzyme inhibition and protein binding studies with allopurinol, oxipurinol and 6-mercaptopurine.

    British journal of clinical pharmacology·2012
    Same author

    Metabolism of 4-pyridone-3-carboxamide-1-beta-D-ribonucleoside triphosphate and its nucleoside precursor in the erythrocytes.

    Nucleosides, nucleotides & nucleic acids·2008
    Same author

    4-pyridone-3-carboxamide ribonucleoside triphosphate accumulating in erythrocytes in end stage renal failure originates from tryptophan metabolism.

    Clinical and experimental medicine·2008
    Same author

    The novel nucleotide 4KNTP, in high concentrations in erythrocytes of renal failure children: a comparison with accumulation of other putative precursors in the plasma.

    Nucleosides, nucleotides & nucleic acids·2006
    Same journal

    Sensorineural hearing loss, iritis and ankylosing spondylitis.

    British journal of rheumatology·1999
    Same journal

    Outcome in systemic vasculitis.

    British journal of rheumatology·1999
    Same journal

    Infection with an unenveloped DNA virus (TTV) associated with non-A to G hepatitis in patients with rheumatoid arthritis.

    British journal of rheumatology·1999
    Same journal

    Aortitis in relapsing polychondritis.

    British journal of rheumatology·1999
    Same journal

    Successful treatment with antithymocyte globulin and cyclosporin A of a severe aplastic anaemia associated with an eosinophilic fasciitis.

    British journal of rheumatology·1999
    Same journal

    Haemophagocytic syndrome in a patient with dermatomyositis.

    British journal of rheumatology·1999
    See all related articles

    Beer consumption significantly elevates plasma uric acid levels in gout patients due to its purine content and ethanol effects. This study highlights beer

    Area of Science:

    • Metabolic disorders
    • Gout pathophysiology
    • Nutritional biochemistry

    Background:

    • Gout is characterized by hyperuricemia, often influenced by diet.
    • Understanding beverage impacts on uric acid metabolism is crucial for gout management.

    Purpose of the Study:

    • To investigate the effects of beer and squash consumption on uric acid levels in gout patients.
    • To elucidate the mechanisms behind beer-induced hyperuricemia.

    Main Methods:

    • Controlled study involving five gouty and five normouricaemic men.
    • Administration of beer or squash over a 4-hour period for two consecutive days.
    • Monitoring of serum lactate, plasma uric acid, urate clearance, and 24-hour uric acid excretion.

    Main Results:

    Related Experiment Videos

    • Both beer and squash increased serum lactate.
    • Plasma uric acid elevation was observed exclusively after beer consumption.
    • Beer consumption significantly increased 24-hour uric acid excretion and urate clearance.
    • Guano sine identified as a primary, readily absorbed purine in beer.

    Conclusions:

    • Beer consumption exacerbates hyperuricemia in gout patients through purine digestion and ethanol's effect on uric acid synthesis.
    • Ethanol, not just purines, contributes to beer's hyperuricemic effect.
    • No evidence suggests beer reduces renal uric acid excretion at typical intake levels.