Different effects of D-glucose anomers on enhanced secretion of gastric acid in rat

The injection of alpha-, beta-, or equilibrated (alpha: 36%, beta: 64%) D-glucose solution into the cranial side of the carotid artery decreased gastric acid output caused by insulin in rats with bilateral adrenalectomy. This effect was not reproduced after vagotomy at the cervical level. Of the 3 forms of D-glucose solution the effect of beta-D-glucose was greatest. The injection of isotonic NaCl solution, however, produced no change in acid output. These results suggest that blood beta-D-glucose may play a predominant role in activating a brain mechanism which controls gastric acid secretion via the vagus nerve.