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Scanning electron microscopy of upper urinary tract tumors
Cancer
|September 1, 1984
Summary
Pleomorphic microvilli, observed via scanning electron microscopy (SEM), are not reliable indicators of upper urinary tract tumors. Their presence likely signifies normal cell turnover rather than malignancy.
Area of Science:
- Urology
- Pathology
- Electron Microscopy
Background:
- Scanning electron microscopy (SEM) is used to examine cell surface morphology.
- Pleomorphic microvilli have been suggested as potential markers for upper urinary tract tumors.
Purpose of the Study:
- To investigate the diagnostic value of pleomorphic microvilli in upper urinary tract lesions.
- To determine if pleomorphic microvilli are specific indicators of tumors or preneoplastic conditions.
Main Methods:
- SEM analysis of upper urinary tract specimens from patients with tumors and benign lesions.
- Examination of normal bladder epithelium after cell removal.
Main Results:
- Pleomorphic microvilli were observed in low-grade tumors, benign lesions (inverted papilloma, fibroepithelial polyp, hydronephrosis), and normal bladders.
- SEM appearance of lining cells was similar across tumor, inflammatory, and proliferative lesions.
Conclusions:
- Pleomorphic microvilli are not specific markers for preneoplastic hyperplasia or tumors of the upper urinary tract.
- Their presence likely indicates increased superficial epithelial cell shedding and replacement.
- The diagnostic significance of pleomorphic microvilli in preoperative diagnosis requires re-evaluation.