Prevention by progesterone of cervicovaginal lesions in neonatally estrogenized BALB/c mice

Instillation of progesterone into the vaginal lumen of BALB/c mice treated neonatally with 25 micrograms 17 beta-estradiol resulted in a significant decrease in vaginal concretions (P less than 0.025), vaginal cornification (P less than 0.025) and vaginal lesions (P less than 0.05).