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Updated: Aug 12, 2026

Establishment and Characterization of UTI and CAUTI in a Mouse Model
08:40

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Published on: June 23, 2015

[Vesical instability and reflux: frequent pathogenic association]

D Aubert

    Chirurgie Pediatrique
    |January 1, 1984
    PubMed

    Insights

    Uninhibited bladder is common in children with reflux, often leading to bilateral, moderate cases. This condition can worsen reflux and impact treatment outcomes, despite anticholinergic ineffectiveness.

    Area of Science:

    • Pediatric Urology
    • Neurourology

    Context:

    • Vesicoureteral reflux (VUR) affects children, with a significant portion also exhibiting bladder dysfunction.
    • Understanding the interplay between bladder behavior and VUR is crucial for effective management.

    Purpose:

    • To investigate the association between uninhibited bladder and vesicoureteral reflux in children.
    • To evaluate the impact of this association on reflux characteristics and treatment outcomes.

    Summary:

    • A study of 175 children (4-15 years) with reflux found 35% had associated uninhibited bladder.
    • This association frequently involved bilateral, grade 2 reflux and could predispose to VUR, especially with abnormal orifices.
    • Anticholinergic drugs showed limited benefit and potentially negative effects on reflux evolution.

    Impact:

    • Uninhibited bladder pathology does not affect surgical reimplantation quality but can decrease functional results, including residual voiding issues and recurrent infections.
    • This highlights the importance of addressing bladder dysfunction in pediatric reflux management for improved functional outcomes.

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