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Effect of oral amrinone on platelet function and survival
Clinical Pharmacology and Therapeutics
|August 1, 1984
Summary
Amrinone can cause thrombocytopenia (low platelet count) in many patients. This study found amrinone did not uniformly affect platelet survival, suggesting low platelets may be an idiosyncratic reaction.
Area of Science:
- Cardiology
- Hematology
- Pharmacology
Background:
- Amrinone is a cardiotonic agent.
- It is associated with reversible thrombocytopenia in 20-50% of patients.
- The mechanism underlying amrinone-induced thrombocytopenia remains unclear, with uncertainty regarding whether it's an idiosyncratic reaction or a toxic effect on platelet survival.
Purpose of the Study:
- To prospectively evaluate the effect of oral amrinone on platelet function and survival.
- To investigate the mechanism of amrinone-induced thrombocytopenia.
Main Methods:
- Prospective evaluation of seven subjects in a clinical trial of chronic oral amrinone therapy.
- Assessment of platelet function and platelet survival.
Main Results:
- No consistent effect of amrinone on platelet function was observed.
- No consistent effect of amrinone on platelet survival was observed.
- Individual patient data showed variability in response.
Conclusions:
- Amrinone does not appear to have a uniform effect on platelet survival.
- The development of thrombocytopenia in patients receiving amrinone may represent an idiosyncratic reaction rather than a direct toxic effect on platelet survival.