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Related Experiment Videos

Capillary permeability in septic patients.

H Ellman

    Critical Care Medicine
    |August 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Sepsis increases capillary permeability throughout the body, not just in the lungs. This generalized increase in permeability contributes to severe edema and pulmonary edema (PE) in septic patients.

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    Area of Science:

    • Cardiovascular Physiology
    • Critical Care Medicine
    • Pathophysiology

    Background:

    • Sepsis is associated with increased capillary permeability, potentially leading to pulmonary edema (PE).
    • The extent to which this increased permeability is systemic versus localized to the lungs remains unproven.

    Purpose of the Study:

    • To investigate the relationship between serum and edema fluid colloid osmotic pressure in septic and nonseptic patients with severe generalized edema.
    • To determine if increased capillary permeability during sepsis is a generalized phenomenon.

    Main Methods:

    • Compared colloid osmotic pressure of serum (COPS) and edema fluid (COPE) in 16 septic and 19 nonseptic patients.
    • Calculated the COPE/COPS ratio to assess capillary permeability.
    • Correlated COPE/COPS ratio with the presence of sepsis and pulmonary edema.

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    Main Results:

    • Septic patients exhibited significantly higher COPE (2.4 +/- 0.7 torr) compared to nonseptic patients (1.3 +/- 0.7 torr).
    • The COPE/COPS ratio was significantly higher in septic patients (0.165) than in nonseptic patients (0.084).
    • A COPE/COPS ratio greater than 0.1 effectively distinguished septic from nonseptic patients.

    Conclusions:

    • The data suggest that increased capillary permeability during sepsis is a generalized systemic process.
    • This generalized increase in permeability contributes to severe edema and may play a role in the development of pulmonary edema in sepsis.