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Related Experiment Videos

Propranolol-induced psychosis.

D J McGahan, A Wojslaw, V Prasad

    Drug Intelligence & Clinical Pharmacy
    |July 1, 1984
    PubMed
    Summary

    A patient developed psychosis, including hallucinations and paranoia, while on hypertension medications. Switching from propranolol to atenolol resolved these psychiatric symptoms, suggesting a link between propranolol and psychosis.

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    Area of Science:

    • Neuropsychopharmacology
    • Cardiovascular medicine

    Background:

    • Hypertension management often involves multiple medications.
    • Beta-blockers are commonly used for treating high blood pressure.

    Observation:

    • A 53-year-old male with uncontrolled hypertension was treated with propranolol, furosemide, and minoxidil.
    • The patient subsequently experienced new-onset paranoid ideations, illusions, combativeness, and visual hallucinations.

    Findings:

    • Psychotic symptoms emerged shortly after the initiation of antihypertensive therapy.
    • Substitution of atenolol for propranolol led to the complete resolution of all psychotic behaviors.

    Implications:

    • This case highlights a potential adverse effect of propranolol, specifically drug-induced psychosis.
    • Clinicians should consider beta-blocker-induced psychosis in patients presenting with new-onset psychiatric symptoms during antihypertensive treatment.
    • Atenolol may be a safer alternative for patients with a history of or predisposition to psychosis.

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