The effect of secretin on colonic mucin secretion rate in the dog

A method of quantitation of mucin using chondroitin sulfate A as a standard has been modified and applied to timed mucin collections from surgically created isolated colonic fistulas in 8 dogs. 25 experiments were conducted in which the effect of secretin was tested in 5. The mucin assay is precise and showed increased colonic mucin secretin in response to secretin. This model appears suitable for pharmacologic assessment of potential drugs for augmenting colonic mucin secretin in states of impaired colonic motility.