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Related Experiment Videos

[Parenteral replacement of thyroid hormones].

A Miyauchi, K Kataoka, Y Suzuki

    Nihon Naibunpi Gakkai Zasshi
    |January 20, 1984
    PubMed
    Summary

    Parenteral thyroid hormone replacement is effective for hypothyroid patients receiving intravenous nutrition. Intravenous l-thyroxine normalized thyroid hormone levels within days, establishing a safe and effective treatment option.

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    Area of Science:

    • Endocrinology
    • Pharmacology
    • Clinical Nutrition

    Background:

    • Parenteral nutrition requires careful consideration for thyroid hormone replacement in hypothyroid or athyroid patients.
    • Intravenous hyperalimentation presents unique challenges for maintaining euthyroid status.

    Observation:

    • Three patients with severe hypothyroidism post-thyroidectomy were treated with parenteral thyroid hormone replacement.
    • Two patients received intravenous l-thyroxine, while one received desiccated thyroid via enema followed by intravenous l-thyroxine.

    Findings:

    • Intravenous l-thyroxine rapidly normalized serum thyroxine and triiodothyronine levels within 7 and 11 days, respectively.
    • Thyroid-stimulating hormone (TSH) levels decreased to normal within 14 days of intravenous therapy.

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  • A maintenance dose of 75 micrograms/day (1.83 micrograms/kg/day) of l-thyroxine was established for long-term therapy.

    • Implications:

    • Parenteral thyroid hormone therapy, particularly intravenous l-thyroxine, is a viable and effective treatment for hypothyroid patients on parenteral nutrition.
    • This approach ensures adequate thyroid hormone levels, preventing complications associated with hypothyroidism in critically ill patients.
    • The study provides crucial data on dosing and therapeutic response for managing thyroid dysfunction in patients receiving intravenous hyperalimentation.