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Pyrithione: plasma metabolite in man

J H Wedig, S J Barbee, C Mitoma

    Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
    |June 1, 1984
    PubMed

    Insights

    2-Methylsulfonylpyridine (2-MSP) is the final pyrithione metabolite found in plasma across multiple animal species. This study confirms 2-MSP is also the human terminal metabolite, establishing species identity.

    Area of Science:

    • Toxicology
    • Pharmacokinetics
    • Metabolism studies

    Background:

    • Pyrithione compounds are used in various applications.
    • Understanding drug metabolism is crucial for safety assessment.
    • Previous studies identified 2-Methylsulfonylpyridine (2-MSP) as a terminal metabolite in several animal models.

    Purpose of the Study:

    • To determine if 2-Methylsulfonylpyridine (2-MSP) is the terminal plasma metabolite in humans.
    • To compare the terminal pyrithione metabolite in humans with that of rats, rabbits, dogs, and monkeys.

    Main Methods:

    • Detection of 2-Methylsulfonylpyridine (2-MSP) in the systemic circulation.
    • Analysis of plasma samples from humans occupationally exposed to pyrithione-related chemicals.

    Main Results:

    • 2-Methylsulfonylpyridine (2-MSP) was identified as the terminal plasma metabolite in humans.
    • The identified human metabolite is identical to the one found in rats, rabbits, dogs, and monkeys.

    Conclusions:

    • The terminal plasma metabolite of pyrithione is conserved across species, including humans.
    • This finding has implications for toxicological risk assessment and understanding pyrithione biotransformation.

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