Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug-nutrient interactions and their implications for safety evaluations.

M W Conner, P M Newberne

    Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
    |June 1, 1984
    PubMed
    Summary

    Drug-nutrient interactions are relevant to rodent toxicologic studies, but variable rodent diets complicate their recognition. Standardized, open-formula diets are recommended for accurate safety evaluations.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Coal combustion aerosols and sulfur dioxide: an interdisciplinary analysis.

    Environmental science & technology·2012
    Same author

    Safety assessment of gamma-cyclodextrin.

    Regulatory toxicology and pharmacology : RTP·2004
    Same author

    Time course of bleomycin-induced lung fibrosis.

    International journal of experimental pathology·2002
    Same author

    Francis J.C. Roe--and a galvanizing trail.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2002
    Same author

    The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. Flavor and Extract Manufacturers Association.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2002
    Same author

    Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor.

    Cancer research·2000

    Area of Science:

    • Toxicology
    • Nutritional Science
    • Laboratory Animal Science

    Background:

    • Drug-nutrient interactions can influence toxicologic study outcomes.
    • Rodent diets vary in nutrient content, complicating interpretation of safety studies.
    • Commercial rodent diets may contain adequate or excess nutrient levels, potentially masking or altering interactions.

    Purpose of the Study:

    • To assess the relevance of drug-nutrient interactions in routine toxicologic studies.
    • To evaluate the suitability of current rodent diets for safety evaluations.
    • To address the impact of diet composition variability on study results.

    Main Methods:

    • Comparison of nutrient concentrations in drug-nutrient interactions with those in standard rodent diets.

    Related Experiment Videos

  • Consideration of diet composition variability in lifetime toxicity/carcinogenicity bioassays.
  • Discussion of the implications of using natural ingredient versus purified diets.

    • Main Results:

    • Drug-nutrient interactions can occur at adequate or excess nutrient levels found in commercial diets.
    • Variability in rodent diet composition and inadequate description hinder recognition of interactions.
    • Purified diets may increase sensitivity to chemical carcinogens, potentially leading to false positive results.

    Conclusions:

    • Accurate interpretation of safety evaluation studies requires rigorous definition of diet composition.
    • Open-formula diets with reported nutrient concentrations are recommended for greater confidence.
    • Consideration should be given to reduced protein diets for adult and aging rodents.