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Related Experiment Videos

Lidocaine and amitriptyline interaction during experimental haemoperfusion.

A Heath, B Löfström, E Mårtensson

    Human Toxicology
    |June 1, 1984
    PubMed
    Summary

    Lidocaine does not improve the removal of amitriptyline during hemoperfusion (HP). This study found lidocaine did not enhance myocardial performance in amitriptyline-intoxicated dogs, with metabolism occurring in the liver and lungs.

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    Area of Science:

    • Pharmacology
    • Toxicology
    • Cardiovascular Physiology

    Background:

    • Amitriptyline overdose can cause severe cardiovascular complications.
    • Hemoperfusion (HP) is a potential treatment for drug intoxication.
    • Lidocaine is sometimes used to manage cardiac arrhythmias in amitriptyline toxicity.

    Purpose of the Study:

    • To investigate the efficacy of lidocaine in enhancing amitriptyline removal during HP.
    • To assess the effect of lidocaine on myocardial performance in amitriptyline-intoxicated dogs during HP.
    • To determine the distribution and metabolism of amitriptyline during HP.

    Main Methods:

    • Hemoperfusion (HP) was performed on five beagle dogs with induced amitriptyline intoxication.
    • Lidocaine was administered to assess its displacement effect on amitriptyline clearance.

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  • Cardiac function was monitored, and drug concentrations were measured in blood and tissues post-necropsy.

    • Main Results:

    • Lidocaine did not significantly improve amitriptyline removal during HP (2% of dose removed).
    • Lidocaine clearance during HP was high (0.99), with 13% removed.
    • Highest amitriptyline concentrations were in the brain and lungs; liver and lungs showed the lowest amitriptyline/nortriptyline ratio, indicating metabolism.

    Conclusions:

    • Lidocaine does not enhance amitriptyline removal via hemoperfusion.
    • Lidocaine does not improve cardiac function in amitriptyline-intoxicated dogs during HP.
    • The liver and lungs are significant sites for amitriptyline metabolism.