Protective effect of metoprolol on emetine induced T wave changes in animals

We studied the protective effect of metoprolol on emetine induced T wave changes in rabbits. None of the rabbits who were beta-blocked before administration of emetine develop the T wave changes observed consistently in the control group. These observations support our clinical impression that emetine-induced T wave changes are produced because of stimulation of peripheral sympathetic nervous system and can be effectively prevented by prior and concomitant beta-blockade.