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Related Experiment Videos

Asthma and bacterial sinusitis in children.

R Friedman, M Ackerman, E Wald

    The Journal of Allergy and Clinical Immunology
    |August 1, 1984
    PubMed
    Summary

    Bacterial sinusitis is common in children with asthma exacerbations. Antibiotic treatment improved asthma symptoms and pulmonary function in most patients, suggesting a link between bacterial sinus infections and asthma severity.

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    Area of Science:

    • Pediatric Pulmonology
    • Otolaryngology
    • Infectious Diseases

    Background:

    • Sinusitis is frequently observed in children with asthma, but the underlying mechanisms, particularly the role of bacterial infection, remain unclear.
    • Asthma exacerbations can be influenced by various factors, and concurrent sinusitis may complicate management.

    Purpose of the Study:

    • To investigate the association between bacterial sinusitis and asthma exacerbations in children.
    • To evaluate the clinical response to antibiotic therapy in asthmatic children with confirmed sinusitis.

    Main Methods:

    • Eight children with asthma exacerbation and radiographic evidence of maxillary sinusitis were studied.
    • Maxillary sinus aspirates were cultured for bacteria.
    • Patients received antibiotic treatment for 14-28 days, alongside standard asthma care.

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  • Clinical improvement was assessed using symptom diaries and pulmonary function tests.

    • Main Results:

    • Bacterial pathogens were identified in five of eight sinus aspirates, including Branhamella catarrhalis, nontypeable Hemophilus influenzae, and Streptococcus pneumoniae.
    • Seven of eight patients showed clinical improvement after antibiotic therapy, including all with positive sinus cultures.
    • Pulmonary function tests improved in five of seven patients, and asthma symptom scores improved in all five who kept diaries.

    Conclusions:

    • Bacterial infection is a significant factor in sinusitis associated with asthma exacerbations in children.
    • Antibiotic treatment for bacterial sinusitis can lead to clinical improvement in asthma symptoms and pulmonary function.
    • Further research is warranted to elucidate the complex interplay between sinusitis and asthma in pediatric populations.