Subacute oral toxicity of tri-n-butyl phosphate in the Sprague-Dawley rat

Tri-n-butyl phosphate was administered by gavage to male and female Sprague-Dawley rats for 14 consecutive days (low dose: 0.14 ml kg-1; high dose: 0.42 ml kg-1). Effects of this chemical were investigated at the end of the feeding period. Histopathological examination of the testes (high-dose group) showed the presence of microscopic degenerative changes in the seminiferous tubules. No other abnormal microscopic changes were observed.