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Related Experiment Videos

The crystallization behaviour of sulphathiazole.

D Jordan, J E Carless

    The Journal of Pharmacy and Pharmacology
    |May 1, 1976
    PubMed
    Summary

    This study reveals sulphathiazole crystallization kinetics change with temperature. Above 34°C, crystallization is first order, but below this temperature, it becomes third order, impacting drug formulation.

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    Area of Science:

    • Pharmaceutical Science
    • Physical Chemistry
    • Chemical Engineering

    Background:

    • Previous studies indicated sulphathiazole Form 1 dissolution kinetics are first order but deviate below 37°C.
    • Surface reaction becomes rate-limiting at lower temperatures during dissolution.

    Purpose of the Study:

    • To investigate the crystallization kinetics of sulphathiazole Form 1.
    • To determine the effect of temperature on crystallization kinetics within the 25°C to 50°C range.

    Main Methods:

    • Kinetic analysis of sulphathiazole crystallization.
    • Experimental temperature control between 25°C and 50°C.

    Main Results:

    • Crystallization kinetics are temperature-dependent, with a transition point around 34°C.
    • Above 34°C, sulphathiazole crystallization follows first-order kinetics.
    • Below 34°C, crystallization kinetics shift to third-order, influenced by surface integration.

    Conclusions:

    • Temperature significantly alters sulphathiazole crystallization kinetics, affecting crystal growth.
    • Understanding these kinetic changes is crucial for controlling crystal form and drug product performance.
    • The high-entropy surface integration step is sensitive to temperature and inhibitors.

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