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Increased myocardial adenosine release in heart failure.
Journal of Molecular and Cellular Cardiology
|June 1, 1984
Summary
Heart failure in dogs is linked to reduced response to beta-adrenergic agonists and lower coronary vascular resistance. Studies show elevated adenosine release in failing hearts, potentially causing these issues.
Area of Science:
- Cardiology
- Cardiovascular Physiology
Background:
- Volume overload congestive heart failure is associated with reduced myocardial inotropic responsiveness to beta-adrenergic agonists in both dogs and humans.
- This condition also shows reduced resting coronary vascular resistance, suggesting increased production of metabolic vasodilators in the failing heart.
Purpose of the Study:
- To investigate the hypothesis that heart failure is associated with elevated myocardial production of adenosine.
- To measure myocardial adenosine release in normal dogs and dogs with volume overload heart failure.
Main Methods:
- Measurement of myocardial adenosine release in canine models.
- Comparison of adenosine release between normal dogs and dogs with induced volume overload heart failure.
Main Results:
- Basal levels of myocardial adenosine release were found to be threefold higher in dogs with heart failure compared to normal dogs.
- Elevated adenosine release may contribute to coronary blood flow abnormalities and blunted inotropic response to catecholamines in heart failure.
Conclusions:
- Heart failure is associated with significantly elevated myocardial adenosine release.
- Adenosine may play a role in the pathophysiology of heart failure, affecting both coronary blood flow and myocardial contractility.