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[Clinico-electrophysiologic study of the anti-arrhythmic action of trimecaine]
Insights
Trimecaine hydrochloride effectively treated arrhythmias in 73.9% of patients with coronary heart disease. This antiarrhythmic drug improved sinus node function and conduction, with most side effects being mild and temporary.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Coronary heart disease frequently presents with cardiac rhythm disorders.
- Ventricular and supraventricular arrhythmias require effective antiarrhythmic therapies.
Purpose of the Study:
- To evaluate the antiarrhythmic efficacy and safety of trimecaine hydrochloride.
- To assess the drug's impact on cardiac electrophysiology in patients with coronary heart disease.
Main Methods:
- A study involving 58 patients with coronary heart disease and rhythm disorders.
- Administration of trimecaine hydrochloride via oral and intramuscular routes.
- Monitoring of cardiac rhythm, sinus node function, and conduction parameters.
Main Results:
- Trimecaine hydrochloride demonstrated antiarrhythmic activity in 73.9% of patients.
- The drug prolonged sinus node recovery, inhibited atrioventricular node conduction, and reduced intraatrial conduction time.
- Adverse effects occurred in 17.3% of patients, primarily with oral administration, and were transient.
Conclusions:
- Trimecaine hydrochloride is an effective antiarrhythmic agent for patients with coronary heart disease.
- The drug favorably influences cardiac electrophysiological parameters.
- Trimecaine hydrochloride exhibits an acceptable safety profile with manageable side effects.
Abstract:
The antiarrhythmic activity of trimecaine hydrochloride administered orally and intramuscularly was studied in 58 patients with coronary heart disease accompanied by ventricular and supraventricular rhythm disorders. In 73.9% of the cases the drug exhibited antiarrhythmic action which was reflected in a longer period of the recovery of sinus node function, inhibited conduction in the atrioventricular node and a decreased time of intraatrial conduction. Side effects were observed in 17.3% of the cases mostly with the oral drug; they tended to abate spontaneously 2-4 h after trimecaine hydrochloride withdrawal.