Related Experiment Video
Updated: Aug 22, 2026

Measurement of Antibody Effects on Cellular Function of Isolated Cardiomyocytes
Published on: March 8, 2013
[Mechanisms of the anti-anginal effect of obzidan]
Abstract:
Using the blind method, a group of 91 coronary heart disease patients were studied. A two-week course of obsidan therapy proved to be most effective in patients with two impaired vessels and also in patients with a simultaneous decrease in the heart rate and in the systolic blood pressure during the threshold exercise. A parallel increase in the stroke index during exercise and a decrease in the myocardial contractile function at rest (by echocardiographic findings) suggest that the decrease in the systolic arterial pressure is associated with a negative inotropic effect of the drug. A decrease in the heart rate and myocardial contractility was observed only in patients with initial tachycardia and the intact functional state of the cardiac muscle. The best antianginal response occurs when these effects are combined.
More Related Videos
07:21Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice
Published on: September 28, 2015
14:18Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation In Vivo and Decreasing Galactose-Deficient IgA1 Production In Vitro
Published on: October 13, 2023
Related Concept Videos
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
Antihypertensive Drugs: Angiotensin II Receptor Blockers
Antihypertensive Drugs: Direct Renin Inhibitors
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Antianginal Drugs: Nitrates and β-Blockers
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow. Administered...
Antianginal Drugs: Calcium Channel Blockers and Ranolazine
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...