Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spontaneous osteochondrosis in rats.

M Kato, T Onodera

    Laboratory Animals
    |April 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Spontaneous joint lesions, similar to osteochondrosis in domestic animals, were found in Sprague Dawley rats. Pathological examination revealed cartilage abnormalities in the femur and humerus, affecting male rats more frequently.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Changes of DNA methylation in protooncogenes in the process of radiation-induced transformation of mouse m5S/1M cells in vitro.

    Cancer letters·1992
    Same author

    Purification and characterization of proteinase In, a trypsin-like proteinase, in Escherichia coli.

    European journal of biochemistry·1992
    Same author

    Rolling mouse Nagoya as a mutant animal model of basal ganglia dysfunction: determination of absolute rates of local cerebral glucose utilization.

    Brain research·1992
    Same author

    Multiple pathways for repair of oxidative DNA damages caused by X rays and hydrogen peroxide in Escherichia coli.

    Radiation research·1992
    Same author

    Expression of glial fibrillary acidic protein (GFAP) by cultured angiofibroma stroma cells from patients with tuberous sclerosis.

    Neuropathology and applied neurobiology·1992
    Same author

    [Cytogenetic analysis of lung tumors by in situ hybridization with chromosome-specific DNA probes].

    Nihon Kyobu Shikkan Gakkai zasshi·1992
    Same journal

    Standardized surgical access to the porcine temporomandibular joint: Anatomical basis for translational research.

    Laboratory animals·2026
    Same journal

    Development of animal use in experiments: a brief historical overview.

    Laboratory animals·2026
    Same journal

    The reduction potential of diet board feeding-survival and clinical chemistry of group-housed Sprague Dawley rats in a 24-month study.

    Laboratory animals·2026
    Same journal

    Advancing the 3Rs? Researchers' perspectives on institutional facilitation in Switzerland - Part 2: executive facilitation.

    Laboratory animals·2026
    Same journal

    Recognition of pain and distress.

    Laboratory animals·2026
    Same journal

    Strengthening animal welfare: monitoring humane endpoints in a rat model of mammary tumorigenesis undergoing a ladder resistance training protocol.

    Laboratory animals·2026
    See all related articles

    Area of Science:

    • Comparative pathology
    • Veterinary medicine
    • Rodent models in research

    Background:

    • Spontaneous joint lesions can occur in laboratory animals, potentially impacting research outcomes.
    • Understanding spontaneous joint diseases in Sprague Dawley rats is crucial for interpreting experimental data.

    Purpose of the Study:

    • To characterize spontaneous joint lesions in Sprague Dawley rats.
    • To compare the observed lesions with known conditions like osteochondrosis in domestic animals.

    Main Methods:

    • Pathological examination of 143 Sprague Dawley rats (19-63 weeks old).
    • Macroscopic and microscopic analysis of joint tissues, focusing on femoral condyles and humeral heads.

    Main Results:

    Related Experiment Videos

  • A distinct lesion characterized by thickened articular cartilage and subchondral bone changes was identified.
  • Lesion progression included cartilage fissures, fibrous tissue proliferation, cartilage flaps, and cysts.
  • Incidence in the distal femur was 22.2% in males and 2.8% in females; lesions were identical to osteochondrosis.

    • Conclusions:

    • Sprague Dawley rats can develop spontaneous joint lesions resembling osteochondrosis.
    • These findings highlight the importance of considering spontaneous joint pathology in rat studies.
    • The higher incidence in males suggests potential sex-based susceptibility.