Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Japanese summer-type hypersensitivity pneumonitis: studies using Cryptococcus antigen.

T Miyagawa, S Hamagami, T Ochi

    Clinical Allergy
    |July 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Acinar cell carcinoma of the pancreas with elevated serum alpha-fetoprotein levels: a case report and a review of 28 cases reported in Japan.

    Gastroenterologia Japonica·1992
    Same author

    [Coagulation and fibrinolysis in pregnancy].

    Rinsho byori. The Japanese journal of clinical pathology·1992
    Same author

    [Elevated production of GM-CSF by peripheral blood mononuclear cells stimulated with mite antigens in children with bronchial asthma].

    Arerugi = [Allergy]·1992
    Same author

    [A survey of body temperatures in the elderly and the thermal environment in nursing homes].

    [Nihon koshu eisei zasshi] Japanese journal of public health·1992
    Same author

    [Health status and care of the urban elderly].

    [Nihon koshu eisei zasshi] Japanese journal of public health·1992
    Same author

    [A study of falls experienced by institutionalized elderly].

    [Nihon koshu eisei zasshi] Japanese journal of public health·1992

    Japanese summer-type hypersensitivity pneumonitis may be caused by Cryptococcus neoformans. This study found antibodies against this fungus in most affected patients, suggesting an environmental link.

    Area of Science:

    • Pulmonology
    • Immunology
    • Mycology

    Background:

    • Japanese summer-type hypersensitivity pneumonitis is a seasonal respiratory illness.
    • Diagnosis relies on clinical presentation and seasonal patterns.
    • Environmental exposure is suspected due to symptom recurrence at home.

    Observation:

    • Sixty-six patients diagnosed between 1973-1980 were studied.
    • Acute symptoms like fever, cough, and dyspnea occurred hours after returning home.
    • Symptoms improved spontaneously upon leaving the home environment.

    Findings:

    • Anti-Cryptococcus neoformans antibodies detected in 64/65 patients' sera via indirect immunofluorescence.
    • Precipitating antibodies against Cr. neoformans culture supernatant detected in >80% of active-stage sera.

    Related Experiment Videos

  • Positive inhalation provocation-challenge with Cr. neoformans antigen suggested a causal role.

    • Implications:

    • Cryptococcus neoformans or related species are potential causative agents of Japanese summer-type hypersensitivity pneumonitis.
    • Environmental exposure to Cryptococcus antigens is a likely trigger for this hypersensitivity pneumonitis.
    • Further research into environmental fungal exposure can aid in diagnosis and prevention.