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Related Experiment Videos

Clinical experience with antilymphocyte serum.

M F Heyworth

    Immunological Reviews
    |January 1, 1982
    PubMed
    Summary

    Antilymphocytic sera (ALS) can reduce circulating lymphocytes, but its effectiveness in organ transplantation remains unproven. However, ALS shows promise in treating aplastic anemia by promoting bone marrow regeneration.

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    Area of Science:

    • Immunology
    • Transplantation Medicine

    Background:

    • Antilymphocytic sera (ALS) are used clinically, but their properties vary.
    • The precise mechanisms of ALS action on lymphocytes are not fully understood.

    Purpose of the Study:

    • To review the general effects and clinical utility of antilymphocytic sera in human subjects.
    • To evaluate the efficacy of ALS in organ transplantation and other conditions.

    Main Methods:

    • Review of clinical data and immunological techniques, including E-rosette formation and immunofluorescence.
    • Analysis of fifteen years of experience with ALS in renal transplantation.

    Main Results:

    • ALS administration reduces circulating E-rosette-positive lymphocytes.
    • Evidence does not convincingly support ALS prolonging human renal allograft survival.
    • Bone marrow regeneration observed in aplastic anemia patients treated with ALS.

    Conclusions:

    • The clinical utility of ALS in organ transplantation requires further investigation.
    • ALS may be a potential treatment for aplastic anemia.
    • Development of methods to monitor ALS dosage is needed.
    • Monoclonal antilymphocytic antibodies warrant further study for various clinical applications.

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