Immunodepression in autoimmune reactions (review of literature)

The topicalness of the study of immunodepression developing in the course of autosensitization was pointed out on the basis of an analysis of literary data published both in the USSR and abroad. One of the unfavourable consequences of autosensitization is the reduced resistance of the organism to infection. As evidence of this regularity, the author presents results of research into the immunodepressive effect of experimental homosensitization and of clinical observations of increased morbidity from infectious diseases in persons with expressed autoimmune reactions. Data on the role of various factors leading to the formation of autoallergic reactions and decreased resistance to infection are discussed.