Functional homogeneity of pancreatic islets of aging rats

Islest from different regions of pancreases of aging rats were compared for size and variations of response to glucose stimulation. The results show that pancreatic islets from the ventral-duodenal and splenic regions of 12-mo-old retired breeder. Spraque dawley rats are comparable in all respects measured: thus, pancreatic regional differences cannot explain the age-associated reduction in beta cell secretory response noted in previous studies.