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Controlled trial of imipramine in diurnal enuresis
Archives of Disease in Childhood
|September 1, 1982
Insights
This study investigated imipramine for treating diurnal enuresis in children. Results showed imipramine was not more effective than placebo for childhood enuresis.
Area of Science:
- Pediatric Urology
- Clinical Pharmacology
Background:
- Diurnal enuresis is a common condition in children.
- Treatment options for diurnal enuresis are varied.
- Imipramine is a tricyclic antidepressant with potential anticholinergic effects.
Purpose of the Study:
- To evaluate the efficacy of imipramine compared to placebo in treating diurnal enuresis in children.
Main Methods:
- A double-blind, randomized controlled trial was conducted.
- Twenty-seven children diagnosed with diurnal enuresis participated.
- Participants received either imipramine or a placebo.
Main Results:
- No statistically significant difference in outcome was observed between the imipramine and placebo groups.
- Treatment effectiveness was independent of patient age, gender, bladder capacity, or psychiatric status.
- Some children showed improvement, but this was not exclusively linked to imipramine treatment.
Conclusions:
- Imipramine demonstrated no superior efficacy over placebo for the management of diurnal enuresis in this pediatric cohort.
- Further research may be needed to explore alternative or adjunctive therapies for diurnal enuresis.
Abstract:
Twenty-seven children with diurnal enuresis were studied in a double-blind randomised controlled trial of imipramine. Outcome was not related to such features as age, gender, maximum functional bladder capacity, or evidence of psychiatric disturbance. Although the condition in several children improved, no evidence emerged to suggest that imipramine was superior to placebo in the treatment of the condition.